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Pyrimethamine is a medication used with leucovorin to treat toxoplasmosis and cystoisosporiasis. It is also used with dapsone as a second line option to prevent Pneumocystis jiroveci pneumonia (PCP) in people with HIV/AIDS. It was previously used for malaria but is no longer recommended due to resistance. Pyrimethamine is taken by mouth.
Specification:
|
Appearance |
An almost white crystalline powder or colorless crystals |
|
Identification |
Identification A (IR) Identification B (TEST FOR CHLORIDE) |
|
Clarity and colour of solution |
≤ by6 |
|
Related substance |
Any second spot≤0.25% |
|
Sulphate |
≤80ppm |
|
Melting point |
239-242°c |
|
Ordinary impurities |
Complies stipulate |
|
Ovi |
≤0.2 |
|
Residual solvents |
Complies stipulate |
|
Loss on drying |
≤0.5% |
|
Ash |
≤0.1% |
|
Assay (on dry basis) |
99.0-101.0% |
Packaging details:
|
Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
|
Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
|
Shelf Life: |
5 years if sealed and store away from direct sun light. |
