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Furosemide is a loop diuretic inhibitor of NKCC (Na+/2Cl-/K+) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.
Furosemide is primarily used for the treatment of hypertension and edema. It is the first-line agent in most people with edema caused by congestive heart failure. It is also used for hepatic cirrhosis, renal impairment, nephrotic syndrome, in adjunct therapy for cerebral or pulmonary edema where rapid diuresis is required (IV injection), and in the management of severe hypercalcemia in combination with adequate rehydration.
Specification:
|
ITEMS |
SPECIFICATION |
|
Appearance |
White or almost white powder |
|
Identification |
Meets the requirements |
|
Solubility |
Practically insoluble in water methylene chloride, sparingly soluble in alcohol, slightly soluble in ether, soluble in acetone |
|
Melting Point |
About 210 |
|
Loss on Drying |
≤0.5% |
|
Sulphated Ash |
≤0.1% |
|
Chloride |
≤0.02% |
|
Heavy Metals |
≤20ppm |
|
Sulfate |
≤10ppm |
|
Related Substances |
≤0.5% |
|
Assay |
98.5 ~ 101.0% |
|
Standard |
BP2002 |
Packaging details:
|
Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
|
Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
|
Shelf Life: |
5 years if sealed and store away from direct sun light. |
