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Description:
Amitriptyline Hydrochloride is an antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptakeof norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters.
Usage:
Amitriptyline is used in ankylosing spondylitis for pain relief as a preventive for patients with frequent/chronic migraines. It is also used as a preventive for patients with recurring biliary dyskinesia (sphincter of Oddi dysfunction) Amitriptyline is also used in the treatment of nocturnal enuresis in children.
Specification:
|
Description |
white or practically white, odorless or practically odorless, crystalline powder or small crystals |
|
Solubility |
Freely soluble in water, in alcohol and in Chloroform, and in methanol, insoluble in ether. |
|
Identification: Test A Test B Test C |
BY IR BY UV Test for Chloride |
|
Melting Range |
Between 195.0°C to 199.0°C |
|
Related Substances By TLC |
Any secondary spot : NMT 0.5% Sum of all secondary spots : NMT 1.0% |
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Heavy metals |
Not more than 0.001% |
|
Loss On Drying |
Not more than 0.5% |
Packaging details:
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Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
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Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
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Shelf Life: |
5 years if sealed and store away from direct sun light. |
