Request A Call Back

Category

Nicorandil
Inquiry Submitted Successfully

Nicorandil

  • Product Name : Nicorandil
  • Grade : IP / BP / USP
  • Therapeutic Category : Antianginals
  • CAS No : 65141-46-0
  • COA : Available
  • MSDS : Available

Description

Nicorandil is a vasodilatory drug used to treat angina.

Nicorandil stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle.

 

Specification:

Analysis Test

                              Specification

      Result

 

Description

 

white crystalline powder,odorless

 

Conforms

 

Solubility

 

Easily soluble in water, unsoluble in ethanol

 

Conforms

PH

6.0~7.5

6.9

 

Solution clarity and color

 

solution should be clear and colorless

 

Conforms

 

Related substances

5’CMP 0.3%

Simple impurity

Total other impurity

0.01%

0.03%

0.10%

 

Chloride

0.05%

 

Conforms

 

Ammonium

0.05%

 

Conforms

 

Fe

0.01%

 

Conforms

 

Phosphate

0.1%

 

Conforms

 

Loss on drying

≤6.0%

1.3%

 

Heavy metals

0.002%

 

Conforms

 

Arsenide

0.0001%

 

Conforms

 

Bacterial Endotoxins

0.3EU/mg

 

Conforms

 

Microbial Limit

Conforms

 

Conforms

Assay(on dried basis)

≥98.0%

98.8%

Conclusion: The results conform with BP 2010

 

Packaging details:

 

 

Packaging details:

25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

Storage:

Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat

Shelf Life:

5 years if sealed and store away from direct sun light.

×